Protocolsinfections
infectionsLow-Moderate

Disulfiram (High-Dose) for Lyme

Off-label use of alcoholism drug (Antabuse) at high doses to kill Borrelia persisters.

Evidence Score

74/100

Developer

Kenneth Liegner, Brian Fallon

Duration

6-18 months, sometimes longer

Steps

10 phases

Conditions

3 targeted

Protocol Overview

Off-label use of alcoholism drug (Antabuse) at high doses to kill Borrelia persisters. Emerging as most effective treatment for chronic Lyme. Requires careful monitoring.

Key Resources

Research by Liegner, Fallon, Pothineni, Bay Area Lyme Foundation funded research, online Lyme communities

Safety Profile

Contraindications & Risks
Liver disease, psychosis risk, peripheral neuropathy (can be permanent), pregnancy, alcohol use
Important Notes

Game-changer in Lyme treatment according to many patients. Discovered by Stanford screen. Kills persister forms of Borrelia that other antibiotics miss. Can cause severe side effects (neuropathy, psychosis). Requires close monitoring. Many Lyme patients report sustained remission after years of suffering. Off-label use, not FDA-approved for Lyme. Most exciting Lyme treatment in years.

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EvidenceLow-Moderate
Evidence Score74/100
Categoryinfections
Duration6-18 months, sometimes longer

About Evidence Score

The Evidence Score rates the strength of clinical and scientific evidence behind this protocol. Higher scores indicate stronger research support. This is a research tool, not medical advice.

Educational purposes only. Some alternative protocols carry serious risks. Always consult qualified healthcare professionals before beginning any treatment.