Disulfiram for Persistent Lyme Symptoms
Disulfiram is a prescription drug approved for alcohol use disorder.
22/100
Kenneth Liegner, Brian Fallon
Set by your clinician
8 phases
1 condition
Protocol Overview
Disulfiram is a prescription drug approved for alcohol use disorder. Lab studies found it kills Lyme bacteria (Borrelia burgdorferi), and some clinicians use it off-label for persistent symptoms after Lyme treatment. Human evidence is limited to case reports, a chart review and a very small pilot trial. It has serious side effects and is only used under close clinician supervision.
Used For
Key Resources
Safety Profile
Not FDA-approved for Lyme disease. In the 2025 Columbia pilot study, 9 people with persistent symptoms after treated Lyme took part; 2 stopped because of worsening (one was briefly hospitalized) and 3 were withdrawn for abnormal lab results. A retrospective chart review reported benefit in many patients, but it was uncontrolled and self-reported. Larger controlled trials are needed. Gabriel can help you find a clinician experienced in tick-borne illness.
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Book with GabrielAbout Evidence Score
The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.
For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.