DSIP
Also known as: Delta Sleep-Inducing Peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Neuropeptide that promotes deep sleep and reduces sleep latency through endocrine and neurotransmitter modulation.
Benefits
6
Conditions
6
Evidence
Limited human trials, preclinical studies+ studies
Source
Naturally occurring neuropeptide
Gabriel Brain Score
Moderate
Overview
Neuropeptide that promotes deep sleep and reduces sleep latency through endocrine and neurotransmitter modulation.
Mechanism of Action
Stimulates somatoliberin (GHRH) while inhibiting somatostatin for SWS promotion, modulates NMDA and α1-adrenergic receptors, influences GABA release, reduces corticotropin and stress hormones (~30% reduction), normalizes sleep-wake cycle signaling.
Key Benefits
- ✓Enhances slow-wave sleep (deep sleep)
- ✓Reduces sleep onset latency
- ✓Improves sleep efficiency
- ✓Reduces stress hormones
- ✓Non-sedating sleep normalization
- ✓May help withdrawal symptoms
Clinical Applications
Dosing Guidelines
Subcutaneous injection
Intranasal
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Limited human trials, preclinical studies
Early human trials showed promise for insomnia and sleep quality. Evidence is mixed with some studies showing benefit and others finding limited effects. DSIP analogues may be more effective than native peptide.
Safety Information
Potential Side Effects
- •Minimal
- •Daytime drowsiness (rare)
- •Headache
Contraindications
- Pregnancy
- Breastfeeding
Interactions
- ⚠May potentiate sedatives