CosmeticModerate Evidence

Snap-8

Also known as: Acetyl octapeptide-3

Extended version of Argireline with enhanced potency (~30% more effective) for wrinkle reduction.

Benefits

5

Conditions

5

Evidence

Clinical trials showing superior efficacy to Argireline+ studies

Source

Synthetic octapeptide

Overview

Extended version of Argireline with enhanced potency (~30% more effective) for wrinkle reduction.

Mechanism of Action

Eight amino acid peptide that mimics SNAP-25, destabilizes SNARE complex more effectively than Argireline, blocks synaptic vesicle fusion, reduces muscle contractions, smoother and more potent than hexapeptide version.

Key Benefits

  • More potent than Argireline (~30%)
  • Up to 63% wrinkle depth reduction in 28 days
  • Longer-lasting effects
  • Targets forehead lines, crow's feet
  • Gradual, natural-looking results

Clinical Applications

Deep expression linesForehead wrinklesCrow's feetDynamic wrinkles resistant to ArgirelinePreventative anti-aging

Dosing Guidelines

Topical serum/cream

Typical Dose5-10% concentration
FrequencyTwice daily
DurationResults in 7-28 days, ongoing maintenance

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level
Moderate
Studies

Clinical trials showing superior efficacy to Argireline

Summary

Clinical studies demonstrate 38-63% wrinkle reduction in 28 days. More stable and potent than Argireline. Well-documented cosmetic efficacy.

Safety Information

Potential Side Effects

  • Minimal
  • Rare irritation

Contraindications

  • Allergy to ingredients

Interactions

  • Can combine with Matrixyl or hyaluronic acid

Quick Facts

CategoryCosmetic
SourceSynthetic octapeptide
Legal StatusApproved cosmetic ingredient
Gabriel Brain Score
75/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.