Thymosin Alpha-1
Also known as: Tα1, Thymalfasin, Zadaxin
Synthetic 28-amino acid peptide that modulates immune function through T-cell enhancement and cytokine regulation.
Benefits
6
Conditions
7
Evidence
Multiple clinical trials, FDA orphan drug status, approved in 35+ countries+ studies
Source
Synthetic 28-amino acid peptide
Gabriel Brain Score
Strong
Overview
Synthetic 28-amino acid peptide that modulates immune function through T-cell enhancement and cytokine regulation.
Mechanism of Action
Acts via TLRs on dendritic cells to activate NF-κB and JNK/p38/AP1 pathways, enhances T-cell differentiation and Th1 cytokine production (IFN-γ, IL-2), activates dendritic cells and NK cells, upregulates regulatory T-cells, downregulates pro-inflammatory cytokines.
Key Benefits
- ✓Enhances cellular and humoral immunity
- ✓Activates T-cells and natural killer cells
- ✓Reduces viral load in chronic infections
- ✓Balances immune response (upregulates when low, downregulates when excessive)
- ✓Supports vaccine response
- ✓Anti-inflammatory in autoimmune conditions
Clinical Applications
Dosing Guidelines
Subcutaneous injection
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Multiple clinical trials, FDA orphan drug status, approved in 35+ countries
Strong clinical evidence for hepatitis B/C treatment. Approved in many countries. Meta-analyses support efficacy for immune enhancement and viral infections with excellent safety profile.
Safety Information
Potential Side Effects
- •Injection site reactions
- •Mild flu-like symptoms
- •Headache (rare)
Contraindications
- Pregnancy
- Breastfeeding
Interactions
- ⚠May enhance other immunotherapies