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Also known as: Dimethyltryptamine, 5-MeO-DMT, The Spirit Molecule, The God Molecule
DMT (N,N-Dimethyltryptamine) and its close relative 5-MeO-DMT are among the most potent psychedelics known, producing intense but brief experiences. N,N-DMT, found in many plants and the active component of ayahuasca, creates vivid geometric patterns, encounters with seemingly autonomous entities, a...
Applications
5
Clinical Trials
5
Evidence Tier
emerging
Duration
N,N-DMT: 15-30 minutes vaporized, 4-6 hours in ayahuasca; 5-MeO-DMT: 15-45 minutes
Gabriel Brain Score
Moderate Evidence
DMT (N,N-Dimethyltryptamine) and its close relative 5-MeO-DMT are among the most potent psychedelics known, producing intense but brief experiences. N,N-DMT, found in many plants and the active component of ayahuasca, creates vivid geometric patterns, encounters with seemingly autonomous entities, and profound shifts in consciousness lasting 15-30 minutes when smoked or vaporized. 5-MeO-DMT, found naturally in certain plants and the venom of the Sonoran Desert toad (Incilius alvarius), produces a more unified, often ineffable "white light" experience characterized by ego dissolution and feelings of cosmic unity. Clinical research on 5-MeO-DMT has accelerated dramatically, with multiple Phase 1/2 trials active in 2024-2025. Beckley Psytech's Phase 2b trial of intranasal 5-MeO-DMT (BPL-003) for treatment-resistant depression showed rapid, durable antidepressant effects with MADRS reductions of 10.8-11.1 points at day 8, generally well-tolerated with no serious adverse events. Sublingual formulations are also in trials for anxiety and depression. Imperial College London reported that a single dose of ayahuasca's DMT compound produced significant and lasting depression relief in 2026 research. The rapid onset and short duration make DMT particularly interesting for clinical settings, as the entire experience can occur within a supervised session.
5-MeO-DMT: Limited evidence of traditional use; modern "Bufo ceremonies" popularized since 2015 are neo-shamanic, not indigenous. N,N-DMT: Component of ayahuasca with thousands of years of traditional Amazonian use.
N,N-DMT: 30-50mg vaporized; 5-MeO-DMT: 8-12mg intranasal (BPL-003), 6-12mg sublingual
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Schedule I federally for both N,N-DMT and 5-MeO-DMT. No approved medical use.
Schedule I or equivalent globally. 5-MeO-DMT synthesis occurring in Mexico, Brazil for research.
London, United Kingdom
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