Amino Acids

5-HTP (5-Hydroxytryptophan)

Direct serotonin precursor (crosses BBB); supports mood, sleep, appetite regulation

Gabriel Score

78/ 100Good

CategoryAmino Acids

Applications6 conditions

Forms5-HTP (from Griffonia simplicifolia seeds)

How it works

Direct serotonin precursor (crosses BBB); supports mood, sleep, appetite regulation

Typical Dosage

50-300mg/day (bedtime for sleep, divided for mood)

Used for

DepressionInsomniaAnxietyFibromyalgiaAppetite suppressionMigraines

Practical Guide

Available Forms

5-HTP (from Griffonia simplicifolia seeds)

Natural Food Sources

•Not found in food (from Griffonia seeds)

Dosing should be individualized. Consult a qualified healthcare practitioner.

The Science

Evidence Base

Good78/100

Bypasses tryptophan hydroxylase step; more direct than L-tryptophan; do NOT combine with SSRIs; may cause nausea initially

Works Well With

B6MagnesiumL-theanineMelatonin

Safety Profile

Interactions

Serotonin syndrome risk with SSRIs, MAOIs
May potentiate sedatives

Contraindications

Concurrent SSRI/MAOI use
Carcinoid syndrome
Eosinophilia-myalgia syndrome history

Trusted Brands

ThornePure EncapsulationsNOWJarrow

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CategoryAmino Acids

Applications6

Gabriel Score78/100

Educational purposes only. Consult a qualified healthcare provider before starting any supplement protocol.

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5-HTP (5-Hydroxytryptophan)

Practical Guide

Available Forms

Natural Food Sources

The Science

Evidence Base

Works Well With

Safety Profile

Trusted Brands

Have questions about 5-HTP (5-Hydroxytryptophan)?

Build Your Protocol

Related Supplements

N-Acetyl Cysteine (NAC)

L-Theanine

Creatine Monohydrate

Ready to explore natural options?

5-HTP (5-Hydroxytryptophan)

Practical Guide

Available Forms

Natural Food Sources

The Science

Evidence Base

Works Well With

Safety Profile

Trusted Brands

Have questions about 5-HTP (5-Hydroxytryptophan)?

Build Your Protocol

Related Supplements

N-Acetyl Cysteine (NAC)

L-Theanine

Creatine Monohydrate

Ready to explore natural options?