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Amino Acids
SAMe (S-Adenosyl Methionine)
Universal methyl donor; supports methylation, neurotransmitter synthesis, liver detoxification, joint health
Gabriel Score
80/ 100Excellent
CategoryAmino Acids
Applications5 conditions
FormsSAMe (enteric-coated to protect from stomach acid)
How it works
Universal methyl donor; supports methylation, neurotransmitter synthesis, liver detoxification, joint health
Typical Dosage
400-1600mg/day (divided doses, empty stomach)
Used for
DepressionOsteoarthritisLiver diseaseFibromyalgiaMethylation support
Practical Guide
Available Forms
SAMe (enteric-coated to protect from stomach acid)
Natural Food Sources
- •Produced endogenously from methionine
Dosing should be individualized. Consult a qualified healthcare practitioner.
The Science
Evidence Base
Excellent80/100
Powerful methyl donor; clinically effective for depression and osteoarthritis; enteric coating essential; expensive; take on empty stomach
Works Well With
B-vitamins (methylation)TMGMethylfolateB12
Safety Profile
Interactions
- May interact with antidepressants (serotonin syndrome risk)
- May trigger mania in bipolar
Contraindications
- Bipolar disorder
- Parkinson's disease (may worsen)
Trusted Brands
JarrowLife ExtensionPure EncapsulationsNOW
Build Your Protocol
Work with a practitioner to design a personalized supplement protocol.
Find a PractitionerCategoryAmino Acids
Applications5
Gabriel Score80/100
Educational purposes only. Consult a qualified healthcare provider before starting any supplement protocol.