Amino Acids

SAMe (S-Adenosyl Methionine)

Universal methyl donor; supports methylation, neurotransmitter synthesis, liver detoxification, joint health

Gabriel Score

80/ 100Excellent

CategoryAmino Acids

Applications5 conditions

FormsSAMe (enteric-coated to protect from stomach acid)

How it works

Universal methyl donor; supports methylation, neurotransmitter synthesis, liver detoxification, joint health

Typical Dosage

400-1600mg/day (divided doses, empty stomach)

Used for

DepressionOsteoarthritisLiver diseaseFibromyalgiaMethylation support

Practical Guide

Available Forms

SAMe (enteric-coated to protect from stomach acid)

Natural Food Sources

•Produced endogenously from methionine

Dosing should be individualized. Consult a qualified healthcare practitioner.

The Science

Evidence Base

Excellent80/100

Powerful methyl donor; clinically effective for depression and osteoarthritis; enteric coating essential; expensive; take on empty stomach

Works Well With

B-vitamins (methylation)TMGMethylfolateB12

Safety Profile

Interactions

May interact with antidepressants (serotonin syndrome risk)
May trigger mania in bipolar

Contraindications

Bipolar disorder
Parkinson's disease (may worsen)

Trusted Brands

JarrowLife ExtensionPure EncapsulationsNOW

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CategoryAmino Acids

Applications5

Gabriel Score80/100

Educational purposes only. Consult a qualified healthcare provider before starting any supplement protocol.

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SAMe (S-Adenosyl Methionine)

Practical Guide

Available Forms

Natural Food Sources

The Science

Evidence Base

Works Well With

Safety Profile

Trusted Brands

Have questions about SAMe (S-Adenosyl Methionine)?

Build Your Protocol

Related Supplements

N-Acetyl Cysteine (NAC)

L-Theanine

Creatine Monohydrate

Ready to explore natural options?

SAMe (S-Adenosyl Methionine)

Practical Guide

Available Forms

Natural Food Sources

The Science

Evidence Base

Works Well With

Safety Profile

Trusted Brands

Have questions about SAMe (S-Adenosyl Methionine)?

Build Your Protocol

Related Supplements

N-Acetyl Cysteine (NAC)

L-Theanine

Creatine Monohydrate

Ready to explore natural options?