Ashwagandha
Withania somnifera
Ayurveda, Western adaptation
Adaptogenic via withanolides, modulates cortisol and HPA axis, GABAergic, anti-inflammatory
300-600mg extract 2x daily or 3-6g powder in warm milk
The Science
Active Compounds
Withanolides, sitoindosides, alkaloids
Evidence Base
Indian ginseng; reduces cortisol; improves sleep; anxiolytic; powder in milk traditional
How to Use
Capsule, powder (milk decoction), tincture
Dosing should be individualized. Consult a qualified herbalist or healthcare practitioner.
Safety Profile
Caution: Ashwagandha
70+ case reports of liver injury. Risk higher with leaf-based extracts, adulterated products, concurrent hepatotoxic medications, or pre-existing liver conditions. Root-only extracts from reputable sources (KSM-66, Sensoril) show strong safety in clinical trials (191 participants, 12 months, no liver effects).
Safe Use Guidance:
Use root-only extracts from reputable brands (KSM-66, Sensoril). Limit initial course to 3 months. Monitor liver enzymes if risk factors present. Avoid if pre-existing liver disease or concurrent hepatotoxic medications.
Sources:
May interact with sedatives, thyroid hormones, immunosuppressants
Pregnancy; hyperthyroidism; autoimmune conditions; nightshade allergy
Source Quality Herbs
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