Ashwagandha
Withania somnifera
Ayurveda, Western adaptation
Adaptogenic via withanolides, modulates cortisol and HPA axis, GABAergic, anti-inflammatory
300-600mg extract 2x daily or 3-6g powder in warm milk
The Science
Active Compounds
Withanolides, sitoindosides, alkaloids
Evidence Base
Indian ginseng; reduces cortisol; improves sleep; anxiolytic; powder in milk traditional
How to Use
Capsule, powder (milk decoction), tincture
Dosing should be individualized. Consult a qualified herbalist or healthcare practitioner.
Safety Profile
Caution: Ashwagandha
Rare liver injury has been reported, sometimes severe, usually 2 to 12 weeks after starting; risk is higher with liver disease, other liver-straining medicines, heavy alcohol use, or leaf-based or adulterated products. One 12-month study of a root extract (191 healthy adults, no comparison group) found no liver enzyme changes. Not recommended in pregnancy or with thyroid or autoimmune disease.
Safe Use Guidance:
Use root-only extracts from reputable brands (such as KSM-66). Limit initial course to 3 months. Monitor liver enzymes if risk factors present. Avoid if pre-existing liver disease or concurrent hepatotoxic medications.
Sources:
May interact with sedatives, thyroid hormones, immunosuppressants
Pregnancy; hyperthyroidism; autoimmune conditions; nightshade allergy; thyroid disease or thyroid medicine unless the prescriber agrees
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