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Hypericum perforatum
Western, European
Inhibits serotonin, dopamine, norepinephrine reuptake; modulates GABA and glutamate receptors
300mg 3x daily (0.3% hypericin standardized)
Hypericin, hyperforin, flavonoids
Major drug interactions; causes photosensitivity; takes 4-6 weeks for effect
Tea, tincture, capsule
Dosing should be individualized. Consult a qualified herbalist or healthcare practitioner.
Strong CYP450 inducer - reduces efficacy of many drugs including birth control, warfarin, SSRIs
Pregnancy; concurrent antidepressants; bipolar disorder; photosensitivity
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