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Western Herbalism

St. John's Wort

Hypericum perforatum

Western, European

Gabriel Score
88/ 100Excellent
EvidenceStrong - comparable to SSRIs for mild-moderate depression
Conditions4 applications
How it works

Inhibits serotonin, dopamine, norepinephrine reuptake; modulates GABA and glutamate receptors

Typical Dosage

300mg 3x daily (0.3% hypericin standardized)

Used for
Mild to moderate depressionanxietyseasonal affective disordernerve pain

The Science

Active Compounds

Hypericin, hyperforin, flavonoids

Evidence Base

Strong - comparable to SSRIs for mild-moderate depression88/100

Major drug interactions; causes photosensitivity; takes 4-6 weeks for effect

How to Use

Tea, tincture, capsule

Dosing should be individualized. Consult a qualified herbalist or healthcare practitioner.

Safety Profile

Interactions

Strong CYP450 inducer - reduces efficacy of many drugs including birth control, warfarin, SSRIs

Contraindications

Pregnancy; concurrent antidepressants; bipolar disorder; photosensitivity

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TraditionWestern Herbalism
EvidenceStrong - comparable to SSRIs for mild-moderate depression
Applications4
Gabriel Score88/100

Educational purposes only. Consult a qualified healthcare provider before starting any herbal protocol.

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