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Western HerbalismHigh GBS Score (88)

St. John's Wort

Hypericum perforatum

Tradition of Use: Western, European

Mechanism of Action

Inhibits serotonin, dopamine, norepinephrine reuptake; modulates GABA and glutamate receptors

Key Conditions & Uses

Mild to moderate depression
anxiety
seasonal affective disorder
nerve pain

Preparation

Tea, tincture, capsule

Dosage

300mg 3x daily (0.3% hypericin standardized)

Active Compounds

Hypericin, hyperforin, flavonoids

Interactions

Strong CYP450 inducer - reduces efficacy of many drugs including birth control, warfarin, SSRIs

Contraindications

Pregnancy; concurrent antidepressants; bipolar disorder; photosensitivity

Evidence Level & Clinical Notes

Evidence Level:

Strong - comparable to SSRIs for mild-moderate depression

Clinical Notes:

Major drug interactions; causes photosensitivity; takes 4-6 weeks for effect

Quick Overview

TraditionWestern Herbalism
GBS Score88/100
Key Uses4

Key Points

Evidence-based information
Traditional wisdom
Safety information
Clinical applications
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This information is for educational purposes. Always consult with a qualified healthcare provider before starting any herbal protocol or supplement regimen.

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