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Also known as: AMPs, Host defense peptides, HDPs
Broad class of innate immune peptides with antimicrobial, immunomodulatory, and wound-healing properties representing next-generation anti-infectives.
Benefits
7
Conditions
6
Evidence
Extensive preclinical research, limited approved therapeutics, clinical trials ongoing+ studies
Source
Natural host defense peptides (human, animal, plant) or synthetic analogs
Gabriel Brain Score
Moderate
Broad class of innate immune peptides with antimicrobial, immunomodulatory, and wound-healing properties representing next-generation anti-infectives.
Diverse mechanisms including membrane disruption (pore formation, carpet model), LPS neutralization, biofilm inhibition, immunomodulation (chemotaxis, cytokine modulation), intracellular targeting, synergy with conventional antibiotics.
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Extensive preclinical research, limited approved therapeutics, clinical trials ongoing
Robust preclinical evidence across diverse AMPs. Multiple candidates in clinical development. Few approved therapeutics yet (e.g., colistin, polymyxin B for resistant infections). Represents promising frontier in anti-infective therapy with potential to address antibiotic resistance crisis.
Family of small cationic antimicrobial peptides that form first line of innate immune defense.
Multifunctional iron-binding glycoprotein with antimicrobial, immunomodulatory, and anti-inflammatory properties.
Tripeptide with potent anti-inflammatory properties derived from alpha-melanocyte-stimulating hormone.