AntimicrobialEmerging Evidence

KPV

Also known as: Lys-Pro-Val, Alpha-MSH derivative

Tripeptide with potent anti-inflammatory properties derived from alpha-melanocyte-stimulating hormone.

Benefits

6

Conditions

6

Evidence

Preclinical studies, limited human case reports+ studies

Source

Synthetic tripeptide derived from α-MSH

Overview

Tripeptide with potent anti-inflammatory properties derived from alpha-melanocyte-stimulating hormone.

Mechanism of Action

Reduces pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), modulates immune response without direct antimicrobial killing, calms excessive inflammation, supports gut barrier function.

Key Benefits

  • Powerful anti-inflammatory effects
  • Reduces inflammatory cytokines
  • Supports gut healing
  • No immune suppression
  • Synergistic with antimicrobial peptides
  • Well-tolerated

Clinical Applications

Inflammatory bowel diseaseColitisChronic inflammationLeaky gutAutoimmune conditionsSystemic inflammation

Dosing Guidelines

Oral

Typical Dose500-1000 mcg
Frequency1-2 times daily
Duration4-12 weeks

Subcutaneous injection

Typical Dose200-500 mcg
FrequencyOnce daily
Duration4-8 weeks

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level
Emerging
Studies

Preclinical studies, limited human case reports

Summary

Strong anti-inflammatory effects in preclinical models. Limited human data but positive case reports for IBD and inflammatory conditions.

Safety Information

Potential Side Effects

  • Minimal
  • Mild GI upset (oral)

Contraindications

  • Pregnancy
  • Breastfeeding

Interactions

  • May complement anti-inflammatory medications

Quick Facts

CategoryAntimicrobial
SourceSynthetic tripeptide derived from α-MSH
Legal StatusResearch compound, not FDA approved
Gabriel Brain Score
80/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.