LL-37
Also known as: Cathelicidin, hCAP-18
Human antimicrobial peptide with broad-spectrum activity against bacteria, fungi, and viruses.
Benefits
6
Conditions
6
Evidence
Extensive in vitro and preclinical studies, limited human trials+ studies
Source
Naturally occurring human cathelicidin, synthesized therapeutically
Gabriel Brain Score
Moderate
Overview
Human antimicrobial peptide with broad-spectrum activity against bacteria, fungi, and viruses.
Mechanism of Action
Disrupts microbial membranes via carpet-like mechanism, binds LPS to neutralize endotoxins and block TLR4, inhibits biofilm formation, exhibits immunomodulatory effects through chemokine induction, promotes wound healing via TGF-β pathway.
Key Benefits
- ✓Broad-spectrum antimicrobial activity
- ✓Anti-biofilm effects
- ✓Neutralizes bacterial endotoxins
- ✓Promotes wound healing
- ✓Modulates immune response
- ✓Antiviral effects
Clinical Applications
Dosing Guidelines
Topical
Subcutaneous injection
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Extensive in vitro and preclinical studies, limited human trials
Well-characterized antimicrobial mechanisms in vitro. Limited human clinical data. Strong preclinical evidence for infection control and wound healing.
Safety Information
Potential Side Effects
- •Injection site reactions
- •Local irritation
- •Potential cytotoxicity at high doses
Contraindications
- Pregnancy
- Breastfeeding
Interactions
- ⚠Unknown
Quick Facts
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