Epithalon
Also known as: Epitalon, Epithalamin, Alanyl-glutamyl-aspartyl-glycine
Khavinson's landmark tetrapeptide that activates telomerase and elongates telomeres for anti-aging effects.
Benefits
7
Conditions
6
Evidence
Khavinson's research group, preclinical animal studies+ studies
Source
Synthetic tetrapeptide derived from pineal gland peptides
Gabriel Brain Score
Strong
Overview
Khavinson's landmark tetrapeptide that activates telomerase and elongates telomeres for anti-aging effects.
Mechanism of Action
Activates telomerase enzyme to elongate telomeres and extend cellular lifespan, regulates gene expression via epigenetic mechanisms, enhances Nrf2 activation to reduce oxidative stress, stimulates pineal melatonin production, inhibits pro-senescence genes (CCl11, HMGB1).
Key Benefits
- ✓Telomere elongation and cellular rejuvenation
- ✓Extends cellular lifespan
- ✓Improves sleep and circadian rhythm via melatonin
- ✓Antioxidant and anti-aging effects
- ✓Supports immune function
- ✓Potential lifespan extension
- ✓Reduces age-related biomarkers
Clinical Applications
Dosing Guidelines
Subcutaneous injection
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Khavinson's research group, preclinical animal studies
Strong preclinical evidence from Khavinson's lab for telomere elongation and lifespan extension in animals. Limited human clinical trials but promising preliminary data. Russian research extensive.
Safety Information
Potential Side Effects
- •Minimal
- •Vivid dreams
- •Mild fatigue initially
Contraindications
- Pregnancy
- Breastfeeding
- Active cancer
Interactions
- ⚠None well-documented