Glutathione
Also known as: GSH, L-Glutathione, Master antioxidant
Tripeptide master antioxidant critical for cellular detoxification, immune function, and longevity.
Benefits
7
Conditions
7
Evidence
Extensive research, limited large RCTs for supplementation+ studies
Source
Naturally occurring tripeptide (Glu-Cys-Gly), synthesized or extracted
Gabriel Brain Score
Strong
Overview
Tripeptide master antioxidant critical for cellular detoxification, immune function, and longevity.
Mechanism of Action
Neutralizes ROS and free radicals via electron donation, conjugates toxins for elimination via glutathione-S-transferases, regenerates other antioxidants (vitamins C and E), supports mitochondrial function, modulates immune cell signaling.
Key Benefits
- ✓Powerful antioxidant and detoxification
- ✓Supports liver function
- ✓Enhances immune system
- ✓Reduces oxidative stress
- ✓Skin lightening (melanin reduction)
- ✓Neuroprotection
- ✓Longevity support
Clinical Applications
Dosing Guidelines
Intravenous infusion
Oral (reduced bioavailability)
Liposomal oral (enhanced absorption)
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Extensive research, limited large RCTs for supplementation
Well-characterized master antioxidant with critical cellular roles. IV administration shows clear benefits for oxidative stress and detoxification. Oral bioavailability debated, liposomal forms may improve absorption. Strong mechanistic rationale.
Safety Information
Potential Side Effects
- •Minimal with IV
- •Rare allergic reactions
- •Abdominal cramping (high oral doses)
Contraindications
- Allergy to glutathione
Interactions
- ⚠May reduce efficacy of some chemotherapy agents