MOTS-c
Also known as: Mitochondrial ORF of the 12S rRNA-c
Mitochondrially-encoded peptide that acts as a metabolic stress hormone promoting longevity.
Benefits
7
Conditions
6
Evidence
Preclinical animal studies, emerging human research+ studies
Source
Mitochondrially-encoded peptide, synthesized therapeutically
Gabriel Brain Score
Strong
Overview
Mitochondrially-encoded peptide that acts as a metabolic stress hormone promoting longevity.
Mechanism of Action
Activates FoxO transcription factors for stress resilience, enhances mitochondrial autophagy (mitophagy), promotes mitochondrial biogenesis, improves glucose and fat metabolism, increases insulin sensitivity, mimics caloric restriction pathways.
Key Benefits
- ✓Enhances metabolic efficiency
- ✓Improves insulin sensitivity
- ✓Promotes mitochondrial biogenesis
- ✓Activates longevity pathways
- ✓Increases energy utilization
- ✓Supports exercise performance
- ✓Mimics caloric restriction benefits
Clinical Applications
Dosing Guidelines
Subcutaneous injection
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Preclinical animal studies, emerging human research
Strong preclinical evidence for metabolic benefits and longevity effects. Limited human data but promising preliminary results. Novel mitochondrial-encoded peptide.
Safety Information
Potential Side Effects
- •Minimal
- •Injection site reactions
- •Transient fatigue
Contraindications
- Pregnancy
- Breastfeeding
Interactions
- ⚠May enhance metformin effects