SS-31
Also known as: Elamipretide, Bendavia, MTP-131
Mitochondria-targeted peptide that repairs inner mitochondrial membrane and restores energy production.
Benefits
6
Conditions
6
Evidence
Multiple Phase II clinical trials, preclinical studies+ studies
Source
Synthetic mitochondria-targeted peptide
Gabriel Brain Score
Strong
Overview
Mitochondria-targeted peptide that repairs inner mitochondrial membrane and restores energy production.
Mechanism of Action
Selectively binds cardiolipin on inner mitochondrial membrane, stabilizes electron transport chain complexes, restores ATP production efficiency, reduces oxidative stress and ROS, eliminates dysfunctional mitochondria while preserving healthy ones, restores redox balance.
Key Benefits
- ✓Restores mitochondrial energy production
- ✓Reduces oxidative damage
- ✓Improves exercise capacity
- ✓Protects against age-related energy decline
- ✓Cardiovascular protection
- ✓Neurodegenerative disease prevention
Clinical Applications
Dosing Guidelines
Intravenous infusion
Subcutaneous injection
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Multiple Phase II clinical trials, preclinical studies
Clinical trials in heart failure and mitochondrial disorders. FDA Fast Track designation for Barth syndrome. Strong preclinical evidence for mitochondrial repair. Promising human safety and efficacy data.
Safety Information
Potential Side Effects
- •Minimal in trials
- •Injection site reactions
- •Headache
Contraindications
- Pregnancy
- Breastfeeding
Interactions
- ⚠None well-documented