Fasting Mimicking Diet (FMD)
A 5-day low-calorie, low-protein, plant-based eating plan (about 800 to 1,100 calories a day) designed to mimic some effects of fasting while still eating.
66/100
Valter Longo
5-day cycles monthly or quarterly
10 phases
3 conditions
Protocol Overview
A 5-day low-calorie, low-protein, plant-based eating plan (about 800 to 1,100 calories a day) designed to mimic some effects of fasting while still eating. Studied in randomized trials for metabolic risk markers; effects on aging and cell renewal come mostly from animal studies. A packaged commercial kit exists, or it can be made from whole foods.
Used For
Key Resources
Safety Profile
In a randomized trial of 100 adults (Wei 2017), three monthly 5-day cycles lowered weight, waist size, blood pressure and IGF-1, with larger changes in people at higher risk. Claims about immune and stem cell renewal come mainly from animal studies. Use in cancer is early research and is discussed with the oncology team. It is milder than water fasting and a middle ground between normal eating and extended fasts.
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The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.
For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.