Protocolstoxicity
toxicityLow

Methylene Blue Protocol

Methylene blue is a prescription drug.

Evidence Score

35/100

Developer

Various researchers (Francisco Gonzalez-Lima and others)

Duration

Decided with your clinician

Steps

9 phases

Used for

2 conditions

Protocol Overview

Methylene blue is a prescription drug. As an IV hospital treatment it is FDA-approved for acquired methemoglobinemia. Low oral doses are being studied off-label for memory and mitochondrial function; human evidence so far is small and early. A licensed clinician decides whether it fits and the dose.

Used For

Memory and cognition (early research)Mitochondrial support (early research)

Key Resources

Francisco Gonzalez-Lima's research on low-dose methylene blue and memory (University of Texas at Austin)
FDA prescribing information for methylene blue injection (acquired methemoglobinemia)

Safety Profile

Contraindications & Risks
G6PD deficiency
Taking SSRIs, SNRIs, MAOIs or other serotonergic drugs (serotonin syndrome risk)
Pregnancy or breastfeeding
Severe kidney disease
Known allergy to methylene blue
Important Notes

FDA-approved in 2016 as an IV injection for acquired methemoglobinemia, with a boxed warning for serotonin syndrome when combined with serotonergic drugs. Small human studies, such as a single-dose brain imaging study in healthy adults (Rodriguez 2016), suggest effects on memory-related brain activity; larger trials are needed. Antiviral effects have been seen in lab studies but are not established in people, and an infection needs proper medical care. Anyone considering it works with a licensed clinician.

Find a Practitioner

Gabriel can find and book a practitioner who works with this approach.

Book with Gabriel
EvidenceLow
Evidence Score35/100
Categorytoxicity
DurationDecided with your clinician

About Evidence Score

The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.

For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.