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Vitamins

Vitamin B9 (Folate)

Methyl donor for DNA synthesis, homocysteine metabolism, neurotransmitter production; essential for cell division

Gabriel Score
92/ 100Excellent
CategoryVitamins
Applications6 conditions
FormsFolic acid (synthetic), L-methylfolate (5-MTHF, active), folinic acid
How it works

Methyl donor for DNA synthesis, homocysteine metabolism, neurotransmitter production; essential for cell division

Typical Dosage

400-800mcg/day (maintenance), 1-5mg/day (therapeutic)

Used for
AnemiaNeural tube defectsDepressionHigh homocysteineCognitive declinePregnancy

Practical Guide

Available Forms

Folic acid (synthetic), L-methylfolate (5-MTHF, active), folinic acid

Natural Food Sources

  • Leafy greens
  • Legumes
  • Asparagus
  • Avocado
  • Liver

Dosing should be individualized. Consult a qualified healthcare practitioner.

The Science

Evidence Base

Excellent92/100

Use methylfolate if MTHFR mutation; folic acid may be problematic for MTHFR variants; essential in pregnancy

Works Well With

B12B6Betaine (TMG)Choline

Safety Profile

Interactions
  • May mask B12 deficiency
  • Interacts with methotrexate, phenytoin, sulfasalazine
Contraindications
  • Undiagnosed B12 deficiency
  • Cancer (controversial)

Trusted Brands

ThornePure EncapsulationsDesigns for Health

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CategoryVitamins
Applications6
Gabriel Score92/100

Educational purposes only. Consult a qualified healthcare provider before starting any supplement protocol.

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