Clinical Genomic Testing
Your genes are the blueprint — learn how to read them
What Gabriel reads for
MTHFR and methylation pathway variants
Phase I and Phase II detoxification genes (CYP450, GST, NAT)
Inflammation genes (TNF-α, IL-6, NF-κB pathways)
Cost
$300–$500
Turnaround
3–5 weeks
Ordering path
3X4 Genetics
Results flow
Upload + interpret in Gabriel
What this test reveals
What this test reveals
Clinical-grade genomic testing goes far beyond consumer DNA kits like 23andMe, analyzing specific gene variants (SNPs) that affect detoxification, methylation, inflammation, nutrient metabolism, and hormonal pathways.
Understanding your genetic blueprint reveals why certain supplements work for you and not others, why you may be a poor detoxifier, and which disease pathways you're genetically predisposed to — allowing for truly personalized prevention strategies.
People usually reach for this kind of diagnostic when they want a clearer read on mthfr and methylation pathway variants, phase i and phase ii detoxification genes (cyp450, gst, nat), inflammation genes (tnf-α, il-6, nf-κb pathways), especially when symptoms or prior testing still leave blind spots.
Once results are back, you can upload them into Gabriel to connect the findings to symptoms, protocols, and next-step testing instead of leaving them as a static report.
Commonly relevant for: Hashimotos Thyroiditis, Autoimmune Disorders, Heart Disease Prevention.
Gabriel difference
Why this becomes more useful inside Gabriel
Genetics loads the gun; environment pulls the trigger. Knowing your genetic variants transforms supplementation from guesswork to precision. A patient with MTHFR mutations needs methylfolate, not folic acid. A slow COMT metabolizer needs different stress support than a fast one. Gabriel integrates genomic data with your other diagnostics to create protocols that work with your unique biochemistry.
Gabriel interprets results through a functional, root-cause lens: optimal ranges, pattern recognition across multiple diagnostics, and what the findings actually mean for action rather than just classification.
That means this test can feed directly into protocols, practitioner matching, food strategy, and follow-up testing instead of ending as a one-off PDF or lab portal result.
What to expect
What to expect from ordering to results
01
Order
Order directly through 3X4 Genetics or ask Gabriel whether there is a better path first.
02
Complete
A simple saliva collection kit mailed to your home. Spit into a tube and mail it back in the prepaid envelope.
03
Interpret
Upload the results to Gabriel for pattern recognition, protocol suggestions, and next-step guidance.
Frequently asked questions
Questions people usually ask before ordering
Genomic testing analyzes your DNA for variations (SNPs) that affect how you metabolize nutrients, medications, hormones, and toxins. It reveals predispositions like MTHFR methylation variants, COMT variants affecting estrogen clearance, CYP450 variants affecting drug metabolism, and APOE variants affecting cardiovascular and Alzheimer's risk.
Consumer tests like 23andMe provide raw genetic data and some health reports. Clinical genomic testing goes deeper with practitioner interpretation, actionable recommendations, and focus on clinically relevant variants. Many practitioners use your 23andMe raw data as a starting point and run it through clinical analysis tools.
Often, yes. Knowing you have MTHFR C677T means you need methylfolate instead of folic acid. COMT variants affect which supplements and medications work best for you. CYP2D6 status determines whether certain antidepressants will work or cause side effects. Genomics moves treatment from guesswork to precision.
This is a valid concern. Clinical labs are bound by HIPAA. Consumer companies vary in their data policies. Read privacy policies carefully, especially regarding data sharing with third parties. Some practitioners recommend clinical-grade testing specifically for stronger privacy protections.
Consumer tests (23andMe, Ancestry) cost $100-200. Clinical panels range from $300-800 depending on depth. Pharmacogenomic testing for medication compatibility is often covered by insurance. One-time test, lifetime value, since your DNA doesn't change.
Not sure which test belongs in your workup?
Tell Gabriel your symptoms, goals, and what you have already tried. You will get a more useful answer than a generic test catalog can give you.