Brain/Cognitive
Phosphatidylserine
Phospholipid component of cell membranes, especially concentrated in brain. Supports neurotransmitter function. Reduces cortisol response to stress. Improves memory and cognitive function in elderly.
Mechanism of Action
Phospholipid component of cell membranes, especially concentrated in brain. Supports neurotransmitter function. Reduces cortisol response to stress. Improves memory and cognitive function in elderly.
Active Compounds
Therapeutic Applications
Serving Size & Preparation
Recommended Serving Size
100-300mg supplement or organ meats
Preparation Guidelines
Supplement (soy or sunflower derived) or from organ meats (brain, liver). Take with fat for absorption
Synergistic Combinations
These foods and compounds enhance the therapeutic effects of Phosphatidylserine:
Additional Notes
Particularly effective for stress-induced cognitive impairment
Safety Information
Contraindications
Blood thinners (monitor), none significant otherwise
Quick Facts
Evidence Level
Related Foods
Wild Salmon/Sardines (Brain)
DHA is primary structural fat in brain (97% of omega-3s in brain). Supports neuronal membrane fluidity, neurotransmitter production. EPA reduces neuroinflammation. Astaxanthin crosses BBB (antioxidant).
Blueberries (Brain)
Anthocyanins cross BBB and accumulate in hippocampus (memory). Increase BDNF (brain-derived neurotrophic factor). Improve neuronal signaling. Reduce oxidative stress and neuroinflammation.
Eggs (Pastured)
Choline precursor to acetylcholine (memory neurotransmitter). Lutein and zeaxanthin accumulate in brain (processing speed). DHA in yolks. B12 prevents brain atrophy.