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Actaea racemosa
Western, Native American
Serotonergic activity, possible estrogen receptor modulation, anti-inflammatory
20-40mg extract 2x daily (standardized to triterpene glycosides)
Triterpene glycosides, cimicifugoside, isoferulic acid
Mechanism unclear (not directly estrogenic); monitor liver function; takes 4-8 weeks
Tincture, capsule
Dosing should be individualized. Consult a qualified herbalist or healthcare practitioner.
May interact with hepatotoxic drugs; theoretically with hormone therapy
Liver disease; pregnancy; hormone-sensitive cancers (debated)
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