Graviola
Annona muricata (Soursop)
Tradition of Use: Caribbean, South American, Southeast Asian
Mechanism of Action
Anticancer via acetogenins (mitochondrial complex I inhibition), antimicrobial, antiparasitic
Key Conditions & Uses
Preparation
Fruit, leaf tea, capsule, juice
Dosage
500-1000mg leaf extract or 1-2 cups tea daily; fresh fruit
Active Compounds
Annonaceous acetogenins, alkaloids, phenols
Interactions
May interact with antihypertensives, diabetes medications; neurotoxicity concerns (theoretical)
Contraindications
Pregnancy; Parkinson's (theoretical neurotoxicity); hypotension
Evidence Level & Clinical Notes
Evidence Level:
Limited - in vitro anticancer activity; neurotoxicity concerns
Clinical Notes:
Soursop; promising anticancer research but no human trials; fruit is safe; leaf extracts more studied; neurotoxicity debated
Quick Overview
Key Points
This information is for educational purposes. Always consult with a qualified healthcare provider before starting any herbal protocol or supplement regimen.
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