Angiotensin 1-7
Also known as: Ang-(1-7), A(1-7)
Protective peptide of the renin-angiotensin system with vasodilatory and anti-inflammatory effects.
Benefits
6
Conditions
6
Evidence
Preclinical studies, early clinical trials+ studies
Source
Endogenous heptapeptide, can be synthesized
Gabriel Brain Score
Strong
Overview
Protective peptide of the renin-angiotensin system with vasodilatory and anti-inflammatory effects.
Mechanism of Action
Binds Mas receptor (counterbalances ACE/Ang II pathway), vasodilation via NO/prostaglandin release, anti-fibrotic and anti-proliferative effects, reduces oxidative stress, anti-inflammatory via reduced cytokines, cardioprotective and neuroprotective actions.
Key Benefits
- ✓Cardiovascular protection
- ✓Vasodilation and blood pressure reduction
- ✓Anti-fibrotic effects
- ✓Neuroprotection
- ✓Anti-inflammatory
- ✓Metabolic benefits (improved insulin sensitivity)
Clinical Applications
Dosing Guidelines
Subcutaneous or intravenous
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Preclinical studies, early clinical trials
Strong preclinical evidence for cardiovascular and metabolic protection. ACE2/Ang-(1-7)/Mas axis well-characterized. Human clinical trials emerging. Interest increased due to ACE2/COVID-19 connection.
Safety Information
Potential Side Effects
- •Unknown in humans (limited data)
- •Theoretical hypotension
Contraindications
- Under investigation
Interactions
- ⚠May interact with ACE inhibitors and ARBs
Quick Facts
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