HormonalStrong Evidence

Vasopressin

Also known as: ADH, Antidiuretic hormone, Arginine vasopressin, Pitressin

Neuropeptide hormone regulating water balance, blood pressure, and cognitive function.

Benefits

6

Conditions

5

Evidence

Extensive clinical use, FDA approved+ studies

Source

Synthetic nonapeptide

Overview

Neuropeptide hormone regulating water balance, blood pressure, and cognitive function.

Mechanism of Action

Binds V1 receptors (vasoconstriction), V2 receptors (kidney water reabsorption via aquaporin-2), and V1b receptors (ACTH release), increases blood pressure via arterial constriction, promotes water retention to concentrate urine, modulates memory consolidation and social behavior.

Key Benefits

  • ✓Regulates fluid balance
  • ✓Increases blood pressure in shock states
  • ✓Treats diabetes insipidus
  • ✓May enhance memory consolidation
  • ✓Supports social recognition
  • ✓Hemostatic effects (increases factor VIII)

Clinical Applications

Diabetes insipidusVasodilatory shock (septic shock)Cardiac arrest (advanced life support)Gastrointestinal bleeding (variceal)Bedwetting (desmopressin analog)

Dosing Guidelines

Intravenous infusion

Typical Dose0.01-0.1 units/min (shock)
FrequencyContinuous infusion
DurationAs clinically indicated

Intranasal (desmopressin analog)

Typical Dose10-40 mcg
FrequencyOnce or twice daily
DurationLong-term for diabetes insipidus

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level
Strong
Studies

Extensive clinical use, FDA approved

Summary

FDA approved for diabetes insipidus and as vasopressor. Well-established clinical use in critical care. Desmopressin (analog) widely used for bedwetting and bleeding disorders. Emerging research on cognitive effects.

Safety Information

Potential Side Effects

  • •Hyponatremia (water intoxication)
  • •Vasoconstriction (ischemia risk)
  • •Headache
  • •Nausea
  • •Abdominal cramping

Contraindications

  • Chronic nephritis
  • Coronary artery disease (relative)
  • Vascular disease

Interactions

  • ⚠Enhanced by carbamazepine and chlorpropamide
  • ⚠Reduced by alcohol and lithium

Quick Facts

CategoryHormonal
SourceSynthetic nonapeptide
Legal StatusFDA approved for multiple indications
Gabriel Brain Score
81/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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