HormonalStrong Evidence

Vasopressin

Also known as: ADH, Antidiuretic hormone, Arginine vasopressin, Pitressin

Neuropeptide hormone regulating water balance, blood pressure, and cognitive function.

Benefits

Conditions

Evidence

Extensive clinical use, FDA approved+ studies

Source

Synthetic nonapeptide

Gabriel Brain Score

Moderate

Overview

Neuropeptide hormone regulating water balance, blood pressure, and cognitive function.

Mechanism of Action

Binds V1 receptors (vasoconstriction), V2 receptors (kidney water reabsorption via aquaporin-2), and V1b receptors (ACTH release), increases blood pressure via arterial constriction, promotes water retention to concentrate urine, modulates memory consolidation and social behavior.

Key Benefits

✓Regulates fluid balance
✓Increases blood pressure in shock states
✓Treats diabetes insipidus
✓May enhance memory consolidation
✓Supports social recognition
✓Hemostatic effects (increases factor VIII)

Clinical Applications

Diabetes insipidusVasodilatory shock (septic shock)Cardiac arrest (advanced life support)Gastrointestinal bleeding (variceal)Bedwetting (desmopressin analog)

Dosing Guidelines

Intravenous infusion

Typical Dose0.01-0.1 units/min (shock)

FrequencyContinuous infusion

DurationAs clinically indicated

Intranasal (desmopressin analog)

Typical Dose10-40 mcg

FrequencyOnce or twice daily

DurationLong-term for diabetes insipidus

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level

Strong

Studies

Extensive clinical use, FDA approved

Summary

FDA approved for diabetes insipidus and as vasopressor. Well-established clinical use in critical care. Desmopressin (analog) widely used for bedwetting and bleeding disorders. Emerging research on cognitive effects.

Safety Information

Potential Side Effects

•Hyponatremia (water intoxication)
•Vasoconstriction (ischemia risk)
•Headache
•Nausea
•Abdominal cramping

Contraindications

Chronic nephritis
Coronary artery disease (relative)
Vascular disease

Interactions

⚠Enhanced by carbamazepine and chlorpropamide
⚠Reduced by alcohol and lithium

Quick Facts

CategoryHormonal

SourceSynthetic nonapeptide

Legal StatusFDA approved for multiple indications

Gabriel Brain Score

81/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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