NeuroprotectiveModerate Evidence

Cerebrolysin

Also known as: Porcine brain peptides, Neurotrophic peptide preparation

Porcine brain-derived neuropeptide preparation with neurotrophic and neuroprotective properties.

Benefits

Conditions

Evidence

Multiple clinical trials, meta-analyses+ studies

Source

Porcine brain tissue extract

Gabriel Brain Score

Moderate

Overview

Porcine brain-derived neuropeptide preparation with neurotrophic and neuroprotective properties.

Mechanism of Action

Mimics endogenous neurotrophic factors (BDNF, NGF), activates PI3K/Akt pathway for neuronal growth and survival, stimulates Sonic Hedgehog pathway for neurogenesis and oligodendrogenesis, reduces excitotoxicity and apoptosis, improves BBB integrity and promotes angiogenesis.

Key Benefits

✓Neuroprotection in stroke and brain injury
✓Enhances neurogenesis and synapse formation
✓Supports cognitive function and memory
✓Promotes recovery from neurological damage
✓Reduces neuroinflammation
✓Improves cerebral blood flow

Clinical Applications

Stroke and cerebrovascular diseaseTraumatic brain injuryAlzheimer's disease and dementiaVascular cognitive impairmentPost-surgical cognitive dysfunctionNeurodegenerative disorders

Dosing Guidelines

Intravenous infusion

Typical Dose10-60 mL in 100-250 mL saline

FrequencyDaily

Duration10-20 days, may repeat courses

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level

Moderate

Studies

Multiple clinical trials, meta-analyses

Summary

Approved in many countries for stroke and dementia. Clinical trials show benefits for cognitive function and stroke recovery. Meta-analyses support efficacy with good safety profile.

Safety Information

Potential Side Effects

•Agitation or hyperactivity
•Insomnia
•Headache
•Injection site reactions
•Rare allergic reactions

Contraindications

Pork allergy
Epilepsy
Severe renal impairment
Pregnancy

Interactions

⚠MAO inhibitors (increased agitation risk)
⚠Antidepressants

Quick Facts

CategoryNeuroprotective

SourcePorcine brain tissue extract

Legal StatusApproved in 50+ countries; not FDA approved

Gabriel Brain Score

84/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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