NeuroprotectiveModerate Evidence

Semax

Also known as: ACTH(4-10) analogue

Russian synthetic peptide derived from ACTH with potent nootropic and neuroprotective effects.

Benefits

7

Conditions

7

Evidence

Multiple Russian clinical trials, preclinical studies+ studies

Source

Synthetic ACTH(4-10) analogue with Pro-Gly-Pro modification

Overview

Russian synthetic peptide derived from ACTH with potent nootropic and neuroprotective effects.

Mechanism of Action

Rapidly upregulates BDNF and TrkB in hippocampus, activates serotonergic and dopaminergic systems, provides neuroprotection against oxidative stress and inflammation, possible melanocortin receptor modulation, enhances neuroplasticity and cognitive function.

Key Benefits

  • ✓Cognitive enhancement and memory improvement
  • ✓Neuroprotection against stroke and hypoxia
  • ✓Reduces anxiety and stress effects
  • ✓Improves focus and attention
  • ✓Supports recovery from brain injury
  • ✓Antidepressant-like effects
  • ✓Immune system modulation

Clinical Applications

Stroke and TIACognitive declineADHD and attention disordersAnxiety and stressOptic nerve diseasePost-concussion syndromeDepression

Dosing Guidelines

Intranasal drops

Typical Dose0.1-1% solution, 2-3 drops per nostril
Frequency2-3 times daily
Duration10-30 days cycles

Subcutaneous injection

Typical Dose0.5-1 mg
FrequencyOnce daily
Duration10-30 days cycles

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level
Moderate
Studies

Multiple Russian clinical trials, preclinical studies

Summary

Approved in Russia for stroke, cognitive disorders, and immune support. Extensive Russian research with limited Western validation. Strong preclinical neuroprotective data.

Safety Information

Potential Side Effects

  • •Nasal irritation
  • •Restlessness
  • •Insomnia (if taken late)
  • •Anxiety (at high doses)

Contraindications

  • Pregnancy
  • Breastfeeding
  • Severe anxiety disorders

Interactions

  • ⚠May potentiate stimulants
  • ⚠Possible interactions with antidepressants

Quick Facts

CategoryNeuroprotective
SourceSynthetic ACTH(4-10) analogue with Pro-Gly-Pro modification
Legal StatusApproved in Russia; research compound in most other countries
Gabriel Brain Score
88/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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