Growth HormoneModerate Evidence

CJC-1295

Also known as: Modified GRF(1-29), DAC:GRF

Long-acting GHRH analog that stimulates sustained growth hormone release.

Benefits

Conditions

Evidence

Clinical trials in healthy adults, ongoing research+ studies

Source

Synthetic GHRH analog

Gabriel Brain Score

Moderate

Overview

Long-acting GHRH analog that stimulates sustained growth hormone release.

Mechanism of Action

Binds GHRH receptors on pituitary somatotrophs, activates adenylyl cyclase/cAMP/PKA cascade, enhances GH gene transcription and protein synthesis, resists degradation for prolonged action (5.8-8.1 day half-life), produces 2-10-fold GH increases and 1.5-3-fold IGF-1 elevation.

Key Benefits

✓Increases growth hormone and IGF-1 levels
✓Enhances muscle growth and recovery
✓Improves body composition
✓Supports fat loss
✓Better sleep quality
✓Enhanced tissue repair
✓Improved skin quality

Clinical Applications

Growth hormone deficiencyAge-related GH declinePoor recovery and healingBody composition optimizationAnti-aging protocols

Dosing Guidelines

Subcutaneous injection

Typical Dose1-2 mg

Frequency1-2 times per week

Duration8-12 weeks, then reassess

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level

Moderate

Studies

Clinical trials in healthy adults, ongoing research

Summary

Clinical evidence for sustained GH and IGF-1 elevation. Safety demonstrated in healthy adults. Long-term effects require further study.

Safety Information

Potential Side Effects

•Injection site reactions
•Water retention
•Increased hunger
•Numbness/tingling
•Fatigue

Contraindications

Active cancer
Diabetic retinopathy
Pregnancy
Breastfeeding

Interactions

⚠May affect glucose metabolism
⚠Caution with insulin

Quick Facts

CategoryGrowth Hormone

SourceSynthetic GHRH analog

Legal StatusResearch compound, not FDA approved

Gabriel Brain Score

81/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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