Growth HormoneModerate Evidence

Sermorelin

Also known as: GRF 1-29, GHRH 1-29

Short-acting GHRH analog that stimulates natural pulsatile growth hormone release from the pituitary.

Benefits

6

Conditions

5

Evidence

Clinical trials, formerly FDA approved+ studies

Source

Synthetic GHRH fragment (amino acids 1-29)

Overview

Short-acting GHRH analog that stimulates natural pulsatile growth hormone release from the pituitary.

Mechanism of Action

Binds GHRH receptors to stimulate endogenous GH secretion, preserves natural pulsatile GH patterns, short half-life requires more frequent dosing, maintains hypothalamic-pituitary feedback loops.

Key Benefits

  • ✓Increases natural GH production
  • ✓Improves sleep quality
  • ✓Enhances recovery and healing
  • ✓Supports muscle growth
  • ✓Improves body composition
  • ✓Maintains physiologic GH patterns

Clinical Applications

Growth hormone deficiencyAge-related GH declinePoor recoverySleep disordersBody composition goals

Dosing Guidelines

Subcutaneous injection

Typical Dose200-500 mcg
FrequencyOnce daily before bed
Duration3-6 months minimum

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level
Moderate
Studies

Clinical trials, formerly FDA approved

Summary

Previously FDA approved for pediatric GH deficiency. Evidence supports GH elevation and IGF-1 increase. Used off-label for anti-aging despite FDA discontinuation of original approval for commercial reasons.

Safety Information

Potential Side Effects

  • •Injection site reactions
  • •Flushing
  • •Headache
  • •Dizziness
  • •Hyperactivity

Contraindications

  • Active cancer
  • Diabetic retinopathy
  • Pregnancy
  • Breastfeeding

Interactions

  • ⚠May affect glucose metabolism

Quick Facts

CategoryGrowth Hormone
SourceSynthetic GHRH fragment (amino acids 1-29)
Legal StatusPreviously FDA approved; available through compounding pharmacies
Gabriel Brain Score
81/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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