Follistatin
Also known as: FST, FS-344
Myostatin inhibitor that promotes dramatic muscle hypertrophy and strength gains.
Benefits
5
Conditions
5
Evidence
Preclinical animal studies, limited human data+ studies
Source
Recombinant human follistatin
Gabriel Brain Score
Moderate
Overview
Myostatin inhibitor that promotes dramatic muscle hypertrophy and strength gains.
Mechanism of Action
Inhibits myostatin (muscle growth limiter), activates IGF-1R/Akt/mTOR pathway for protein synthesis, promotes Smad1/5 signaling, induces muscle hypertrophy even in low-IGF-1 states, increases IGFBP-5.
Key Benefits
- ✓Dramatic muscle hypertrophy
- ✓Increased strength
- ✓Myostatin inhibition
- ✓Enhanced protein synthesis
- ✓Muscle growth independent of exogenous GH/IGF-1
Clinical Applications
Dosing Guidelines
Intramuscular injection
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Preclinical animal studies, limited human data
Strong preclinical evidence for muscle growth in animal models. Human data limited to bodybuilding community reports. Mechanisms well-characterized but human clinical trials lacking.
Safety Information
Potential Side Effects
- •Unknown in humans
- •Potential off-target effects
Contraindications
- Active cancer
- Pregnancy
- Breastfeeding
Interactions
- ⚠May synergize with IGF-1 and MGF
Quick Facts
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