IGF-1 LR3
Also known as: Long R3 IGF-1, Insulin-like Growth Factor-1 Long R3
Long-acting IGF-1 analog with extended half-life that promotes muscle hyperplasia and hypertrophy.
Benefits
6
Conditions
5
Evidence
Preclinical studies, bodybuilding community data+ studies
Source
Recombinant long-acting IGF-1 analog
Gabriel Brain Score
Moderate
Overview
Long-acting IGF-1 analog with extended half-life that promotes muscle hyperplasia and hypertrophy.
Mechanism of Action
Binds IGF-1 receptors with extended half-life, activates PI3K/Akt and MAPK pathways, enhances protein synthesis and nutrient uptake, promotes satellite cell proliferation and differentiation, induces muscle hyperplasia (new cell formation) and hypertrophy.
Key Benefits
- ✓Muscle hyperplasia (new muscle cell growth)
- ✓Enhanced protein synthesis
- ✓Improved recovery
- ✓Nutrient partitioning to muscle
- ✓Fat oxidation
- ✓Tissue repair (muscle, tendon, ligament)
Clinical Applications
Dosing Guidelines
Subcutaneous injection
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Preclinical studies, bodybuilding community data
Well-characterized mechanisms in vitro and animal models. No clinical trials for muscle growth in humans. Widely used in bodybuilding with anecdotal support but lacking formal human safety/efficacy data.
Safety Information
Potential Side Effects
- •Hypoglycemia
- •Joint pain
- •Water retention
- •Organ growth concerns (long-term)
Contraindications
- Active cancer
- Diabetic retinopathy
- Pregnancy
- Breastfeeding
Interactions
- ⚠Affects glucose metabolism
- ⚠Caution with insulin
Quick Facts
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