Ipamorelin
Also known as: NNC 26-0161
Selective ghrelin mimetic that triggers rapid growth hormone release without affecting cortisol or prolactin.
Benefits
6
Conditions
5
Evidence
Clinical trials, safety studies in adults+ studies
Source
Synthetic ghrelin mimetic pentapeptide
Gabriel Brain Score
Moderate
Overview
Selective ghrelin mimetic that triggers rapid growth hormone release without affecting cortisol or prolactin.
Mechanism of Action
Binds ghrelin receptor (GHS-R1a) on pituitary cells, triggers rapid GH release without hypothalamic involvement, no cortisol or prolactin elevation, synergizes with CJC-1295 for optimal pulsatile GH patterns.
Key Benefits
- ✓Rapid GH pulse induction
- ✓No cortisol or prolactin spike
- ✓Improved body composition
- ✓Enhanced recovery
- ✓Better sleep
- ✓Synergistic with GHRH analogs
Clinical Applications
Dosing Guidelines
Subcutaneous injection
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Clinical trials, safety studies in adults
Clinical evidence for selective GH release. Good safety profile with minimal side effects. Often combined with CJC-1295 for synergy.
Safety Information
Potential Side Effects
- •Minimal
- •Increased hunger
- •Water retention (mild)
- •Headache
Contraindications
- Active cancer
- Pregnancy
- Breastfeeding
Interactions
- ⚠Synergistic with GHRH analogs
Quick Facts
Related Peptides
Tesamorelin
Synthetic GHRH analog FDA-approved for reducing visceral adipose tissue in HIV-associated lipodystrophy.
Hexarelin
Potent hexapeptide ghrelin mimetic with strong GH-releasing effects and cardioprotective properties.
CJC-1295
Long-acting GHRH analog that stimulates sustained growth hormone release.