CosmeticEmerging Evidence

Melanotan II

Also known as: MT-II, Melanotan 2

Synthetic α-MSH analog that promotes skin tanning by stimulating melanin production without UV exposure.

Benefits

Conditions

Evidence

Preclinical studies, limited human data+ studies

Source

Synthetic α-MSH analog

Gabriel Brain Score

Emerging

Overview

Synthetic α-MSH analog that promotes skin tanning by stimulating melanin production without UV exposure.

Mechanism of Action

Activates melanocortin-1 receptors (MC1R) on melanocytes, stimulates eumelanin (brown-black pigment) synthesis, also activates MC3R/MC4R causing libido effects, bypasses UV damage while creating tan.

Key Benefits

✓Sunless tanning (even, gradual darkening)
✓Increases photoprotective eumelanin
✓May reduce sunburn risk
✓Libido enhancement (side effect of MC3R/MC4R)
✓Long-lasting pigmentation with maintenance

Clinical Applications

Fair skin prone to burningCosmetic tanningPhotoprotection enhancementLow libido (off-label)

Dosing Guidelines

Subcutaneous injection

Typical Dose250-500 mcg

FrequencyDaily until desired tan, then 1-2x/week maintenance

DurationLoading phase 1-2 weeks, then maintenance

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level

Emerging

Studies

Preclinical studies, limited human data

Summary

Mechanism well-understood. Not FDA approved. Originally developed for skin cancer prevention via eumelanin. Safety concerns include lack of long-term data and unregulated sourcing.

Safety Information

Potential Side Effects

•Nausea
•Flushing
•Spontaneous erections
•Darkening of moles
•Appetite suppression

Contraindications

Melanoma or skin cancer history
Pregnancy
Breastfeeding
Cardiovascular disease

Interactions

⚠Unknown due to lack of clinical trials

Quick Facts

CategoryCosmetic

SourceSynthetic α-MSH analog

Legal StatusNot FDA approved, banned in several countries, unregulated

Gabriel Brain Score

65/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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