Melanotan II
Also known as: MT-II, Melanotan 2
Synthetic α-MSH analog that promotes skin tanning by stimulating melanin production without UV exposure.
Benefits
5
Conditions
4
Evidence
Preclinical studies, limited human data+ studies
Source
Synthetic α-MSH analog
Gabriel Brain Score
Emerging
Overview
Synthetic α-MSH analog that promotes skin tanning by stimulating melanin production without UV exposure.
Mechanism of Action
Activates melanocortin-1 receptors (MC1R) on melanocytes, stimulates eumelanin (brown-black pigment) synthesis, also activates MC3R/MC4R causing libido effects, bypasses UV damage while creating tan.
Key Benefits
- ✓Sunless tanning (even, gradual darkening)
- ✓Increases photoprotective eumelanin
- ✓May reduce sunburn risk
- ✓Libido enhancement (side effect of MC3R/MC4R)
- ✓Long-lasting pigmentation with maintenance
Clinical Applications
Dosing Guidelines
Subcutaneous injection
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Preclinical studies, limited human data
Mechanism well-understood. Not FDA approved. Originally developed for skin cancer prevention via eumelanin. Safety concerns include lack of long-term data and unregulated sourcing.
Safety Information
Potential Side Effects
- •Nausea
- •Flushing
- •Spontaneous erections
- •Darkening of moles
- •Appetite suppression
Contraindications
- Melanoma or skin cancer history
- Pregnancy
- Breastfeeding
- Cardiovascular disease
Interactions
- ⚠Unknown due to lack of clinical trials
Quick Facts
Related Peptides
GHK-Cu
Tripeptide-copper complex that stimulates collagen synthesis, wound healing, and skin regeneration.
Collagen Peptides
Hydrolyzed collagen fragments that support skin, joint, and connective tissue health through oral supplementation.
Snap-8
Extended version of Argireline with enhanced potency (~30% more effective) for wrinkle reduction.