CosmeticModerate Evidence

Palmitoyl Tripeptide

Also known as: Pal-GHK, Biopeptide-CL

Palmitoylated tripeptide that enhances skin penetration and stimulates collagen synthesis for anti-aging.

Benefits

Conditions

Evidence

Cosmetic clinical trials, in vitro studies+ studies

Source

Synthetic palmitoylated tripeptide

Gabriel Brain Score

Moderate

Overview

Palmitoylated tripeptide that enhances skin penetration and stimulates collagen synthesis for anti-aging.

Mechanism of Action

Palmitic acid attachment enhances lipid membrane penetration, signals fibroblasts to increase collagen I and III production, stimulates glycosaminoglycan synthesis, promotes tissue remodeling and repair.

Key Benefits

✓Enhanced collagen production
✓Improved skin firmness
✓Wrinkle reduction
✓Better skin texture
✓Increased dermal thickness
✓Enhanced penetration vs non-palmitoylated peptides

Clinical Applications

Aging skinWrinkles and fine linesLoss of firmnessThin skinPhotodamage

Dosing Guidelines

Topical serum/cream

Typical Dose2-5% concentration

FrequencyOnce or twice daily

DurationOngoing for maintenance

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level

Moderate

Studies

Cosmetic clinical trials, in vitro studies

Summary

Clinical trials show improvements in wrinkle depth and skin elasticity. Well-studied cosmetic ingredient. Palmitoylation enhances efficacy vs non-modified peptides.

Safety Information

Potential Side Effects

•Minimal
•Rare skin irritation

Contraindications

Allergy to ingredients

Interactions

⚠Synergistic with retinoids and vitamin C

Quick Facts

CategoryCosmetic

SourceSynthetic palmitoylated tripeptide

Legal StatusApproved cosmetic ingredient

Gabriel Brain Score

75/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

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