NeuroprotectivePreclinical Evidence

PE-22-28

Also known as: Spadin derivative, TREK-1 antagonist

Synthetic nootropic peptide that enhances cognition through TREK-1 potassium channel inhibition.

Benefits

Conditions

Evidence

Preclinical animal models of depression and cognition+ studies

Source

Synthetic TREK-1 channel antagonist

Gabriel Brain Score

Strong

Overview

Synthetic nootropic peptide that enhances cognition through TREK-1 potassium channel inhibition.

Mechanism of Action

Potently blocks TREK-1 potassium channels (~100-fold more than spadin), increases neuronal excitability and synaptic transmission, upregulates BDNF expression, promotes hippocampal neurogenesis within 4 days, enhances serotonergic transmission.

Key Benefits

✓Rapid cognitive enhancement
✓Improves memory and learning
✓Reduces depression and anxiety
✓Promotes neurogenesis
✓Enhances executive function
✓Fast-acting (effects within days)

Clinical Applications

Depression (treatment-resistant)Cognitive impairmentMemory deficitsStress-related disordersPost-stroke cognitive dysfunction

Dosing Guidelines

Subcutaneous injection

Typical Dose0.5-1 mg

FrequencyOnce daily

DurationResearch protocols typically 4-30 days

* Dosing should be individualized. Always consult with a qualified healthcare practitioner.

Research & Evidence

Evidence Level

Preclinical

Studies

Preclinical animal models of depression and cognition

Summary

Strong preclinical evidence for rapid antidepressant and cognitive effects. No human clinical trials. Faster onset than traditional antidepressants in animal models.

Safety Information

Potential Side Effects

•Unknown in humans
•Potential overstimulation

Contraindications

Pregnancy
Breastfeeding
Seizure disorders

Interactions

⚠Unknown - no human data

Quick Facts

CategoryNeuroprotective

SourceSynthetic TREK-1 channel antagonist

Legal StatusResearch compound, not approved for human use

Gabriel Brain Score

87/ 100

Source Your Protocol

Our preferred peptide partner offers lab-tested, COA-verified peptides with optional physician oversight. Sourced from US-regulated facilities.

Related Peptides

Dihexa

Potent cognitive enhancer that activates hepatocyte growth factor (HGF) pathway for synaptic plasticity.

PreclinicalLearn more →

Semax

Russian synthetic peptide derived from ACTH with potent nootropic and neuroprotective effects.

ModerateLearn more →

Cortexin Derivatives

Khavinson

Synthetic analogs of cortexin bioregulatory peptides with optimized properties for cognitive and neuroprotective applications.

EmergingLearn more →