TB-500
Also known as: Thymosin Beta-4, Tβ4
Naturally occurring peptide that promotes tissue repair, angiogenesis, and reduces inflammation through actin regulation.
Benefits
6
Conditions
6
Evidence
Preclinical animal studies, Phase II human trials for dermal wounds+ studies
Source
Naturally occurring in most cells, synthesized for therapeutic use
Gabriel Brain Score
Strong
Overview
Naturally occurring peptide that promotes tissue repair, angiogenesis, and reduces inflammation through actin regulation.
Mechanism of Action
Binds G-actin to regulate cell migration and actin dynamics, activates PI3K/Akt/eNOS and Notch pathways for angiogenesis, upregulates VEGF and bFGF, reduces inflammatory cytokines via NF-κB modulation, attenuates TGF-β for reduced fibrosis.
Key Benefits
- ✓Accelerates wound healing and tissue repair
- ✓Promotes angiogenesis and blood vessel formation
- ✓Reduces inflammation and scarring
- ✓Enhances cell migration to injury sites
- ✓Supports cardiac repair and regeneration
- ✓Improves hair follicle generation
Clinical Applications
Dosing Guidelines
Subcutaneous injection
* Dosing should be individualized. Always consult with a qualified healthcare practitioner.
Research & Evidence
Preclinical animal studies, Phase II human trials for dermal wounds
Strong preclinical evidence in multiple tissue types. Human trials show safety and efficacy for dermal ulcers. Ongoing research for cardiac and orthopedic applications.
Safety Information
Potential Side Effects
- •Injection site reactions
- •Fatigue
- •Headache
- •Increased hair growth
Contraindications
- Active malignancy
- Pregnancy
- Breastfeeding
Interactions
- ⚠None well-documented