Back to Supplements
Herbs

Berberine

Activates AMPK; improves insulin sensitivity, modulates gut microbiome, antimicrobial

Gabriel Score
88/ 100Excellent
CategoryHerbs
Applications6 conditions
FormsBerberine HCl
How it works

Activates AMPK; improves insulin sensitivity, modulates gut microbiome, antimicrobial

Typical Dosage

500mg 2-3x/day with meals (1000-1500mg/day total)

Used for
Type 2 diabetesPCOSMetabolic syndromeHyperlipidemiaSIBOHypertension

Practical Guide

Available Forms

Berberine HCl

Natural Food Sources

  • Not typically a food (from herbs like goldenseal, barberry)

Dosing should be individualized. Consult a qualified healthcare practitioner.

The Science

Evidence Base

Excellent88/100

"Nature's Metformin"; clinically effective for blood sugar; take with meals; may cause GI upset initially

Works Well With

ChromiumAlpha lipoic acidMilk thistleProbiotics

Safety Profile

Interactions
  • May potentiate diabetes and blood pressure meds
  • Inhibits CYP3A4
  • May affect gut flora
Contraindications
  • Pregnancy
  • Breastfeeding

Trusted Brands

ThornePure EncapsulationsIntegrative TherapeuticsLife Extension

Build Your Protocol

Work with a practitioner to design a personalized supplement protocol.

Find a Practitioner
CategoryHerbs
Applications6
Gabriel Score88/100

Educational purposes only. Consult a qualified healthcare provider before starting any supplement protocol.

Ready to explore natural options?

Connect with a Gabriel practitioner who specializes in evidence-based natural protocols.