Protocolsnutrition
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Acne Clear Skin Protocol

A root-cause protocol for acne that looks at hormones, blood sugar, gut health and inflammation, alongside proven topical care and any prescription treatment your clinician recommends.

Evidence Score

52/100

Developer

Various dermatologists, functional medicine

Duration

2 to 4 months to judge change (skin renews over about a month, and most treatments need 8 to 12 weeks)

Steps

28 phases

Used for

3 conditions

Protocol Overview

A root-cause protocol for acne that looks at hormones, blood sugar, gut health and inflammation, alongside proven topical care and any prescription treatment your clinician recommends.

Used For

Acne vulgariscystic acnehormonal acne

Key Resources

The Clear Skin Diet by Alan Logan and Valori Treloar
American Academy of Dermatology acne guidelines (2024)
Diet and acne research (glycemic load, dairy)

Safety Profile

Contraindications & Risks
Isotretinoin causes severe birth defects; the iPLEDGE program and reliable contraception are required
Never combine vitamin A supplements with isotretinoin or oral retinoids
Spironolactone needs monitoring (potassium) and is not for pregnancy
Retinoids, DIM, saw palmetto and berberine: avoid in pregnancy
Berberine lowers blood sugar and interacts with many medicines; your prescriber must adjust diabetes medicine first
Zinc above 40 mg a day long term can cause copper deficiency
Important Notes

Acne affects up to 50 million Americans a year and about 85% of teens at some point. Four things drive it: extra oil (driven by androgens), clogged pores, acne bacteria and inflammation. The best plans address all four. Diet matters more than dermatology once thought: small trials found a low-glycemic diet improved acne, and observational studies link milk, including skim, to acne. Whey protein may worsen it in some people. A 4 to 6 week dairy trial is easy to try. Hormonal acne often shows on the jawline and chin with flares before periods and may come with PCOS. Spironolactone and birth control pills help many women; a licensed clinician decides whether they fit. Spearmint tea and saw palmetto have limited evidence. The gut-skin connection is an active research area, and probiotics showed promise in small trials. Zinc helps in several small trials. Topical retinoids are among the most effective topicals: they unclog pores and reduce new spots, with irritation in the first 4 to 8 weeks, so start slowly. Adapalene is available over the counter. Isotretinoin is the most effective treatment for severe or scarring acne and brings long-lasting clearance for many people after one course, but it has serious side effects: it causes birth defects (iPLEDGE program required), dries skin, eyes and lips, raises lipids and liver enzymes, and may affect mood, so a clinician monitors it. Acne scars are easier to avoid than to fix: don't pick, and get effective care early. Combining diet, a simple topical routine, attention to hormones and blood sugar, gut health and stress gives most people steady improvement over 3 to 4 months.

Find a Practitioner

Gabriel can find and book a practitioner who works with this approach.

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EvidenceLow-Moderate
Evidence Score52/100
Categorynutrition
Duration2 to 4 months to judge change (skin renews over about a month, and most treatments need 8 to 12 weeks)

About Evidence Score

The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.

For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.