Estrogen Dominance Protocol
Protocol to reduce estrogen dominance (high estrogen relative to progesterone) through improved estrogen metabolism, detoxification, and progesterone support.
80/100
John Lee, Sara Gottfried, functional medicine
3-6 months to rebalance hormones
10 phases
5 targeted
Protocol Overview
Protocol to reduce estrogen dominance (high estrogen relative to progesterone) through improved estrogen metabolism, detoxification, and progesterone support. Common underlying issue in many female hormone problems.
Conditions Treated
Key Resources
Supplements & Herbs
Safety Profile
Estrogen dominance is ratio problem - can have normal or even low estrogen but still be estrogen dominant relative to progesterone. Causes: Stress (lowers progesterone), poor estrogen metabolism (liver burden), xenoestrogens (plastics, pesticides), constipation (estrogen reabsorption), obesity (aromatase in fat). Symptoms: PMS, heavy periods, breast tenderness, fibrocystic breasts, mood swings, weight gain, fibroids, endometriosis. Estrogen metabolism crucial - "good" pathway (2-hydroxyestrogen) vs "bad" pathways (4-OH, 16-OH more carcinogenic). DIM/I3C shift to 2-OH pathway. Calcium-d-glucarate prevents beta-glucuronidase (bacterial enzyme) from deconjugating estrogen in gut (estrobolome). Daily bowel movement essential. Progesterone cream effective but use bioidentical, not synthetic. John Lee pioneered natural progesterone. Topical avoids first-pass liver metabolism. Xenoestrogens add to burden - BPA, phthalates, parabens, pesticides. Filter water (atrazine is estrogenic). DUTCH test shows estrogen metabolites and metabolized estrogen:progesterone ratio.
About Evidence Score
The Evidence Score rates the strength of clinical and scientific evidence behind this protocol. Higher scores indicate stronger research support. This is a research tool, not medical advice.
Educational purposes only. Some alternative protocols carry serious risks. Always consult qualified healthcare professionals before beginning any treatment.