Estrogen Dominance Protocol
A protocol for symptoms often linked to estrogen dominance (high estrogen relative to progesterone), using estrogen clearance, gut and liver support, and progesterone support.
38/100
John Lee, Sara Gottfried, functional medicine
3 to 6 months to see changes
11 phases
5 conditions
Protocol Overview
A protocol for symptoms often linked to estrogen dominance (high estrogen relative to progesterone), using estrogen clearance, gut and liver support, and progesterone support.
Key Resources
Supplements & Herbs
Safety Profile
"Estrogen dominance" is a functional medicine idea rather than a standard diagnosis: estrogen can be normal yet high relative to progesterone. Suggested drivers include stress, slow estrogen clearance, hormone-disrupting chemicals, constipation and extra body fat. Symptoms people link to it include PMS, heavy periods, breast tenderness and mood swings, though fibroids and endometriosis need their own workup. DIM and I3C shift estrogen toward the 2-hydroxy pathway in small studies; whether that improves symptoms is not well tested. Calcium-d-glucarate is used to reduce estrogen recirculation from the gut. John Lee popularized natural progesterone. Daily bowel movements, fiber and fewer plastics are simple, low-risk steps.
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The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.
For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.