High-Dose Vitamin D (Coimbra Protocol)
The Coimbra Protocol uses very high daily vitamin D under a physician, with calcium restriction and close lab monitoring, for autoimmune disease.
35/100
Cicero Coimbra (Coimbra Protocol)
Ongoing only while monitored by your clinician
9 phases
2 conditions
Protocol Overview
The Coimbra Protocol uses very high daily vitamin D under a physician, with calcium restriction and close lab monitoring, for autoimmune disease. Published evidence for the protocol itself is limited to small uncontrolled reports. Separately, a 2025 randomized trial (D-Lay MS) found high-dose vitamin D reduced disease activity in early MS. Doses this high are only ever taken under a licensed clinician with blood and urine monitoring, alongside your neurology or rheumatology care.
Used For
Key Resources
Safety Profile
Developed by Brazilian neurologist Cicero Coimbra. Outcomes are reported mostly through patient accounts and small uncontrolled series, with no randomized trial of the protocol itself. In the D-Lay MS trial, 316 adults with a first MS-like event took high-dose vitamin D every 2 weeks or placebo for 2 years under medical monitoring; disease activity was lower with vitamin D and no serious side effects were linked to it. That dose is far below Coimbra doses. In the VITAL trial, 2,000 IU daily was linked to fewer new autoimmune diagnoses over about 5 years. For people not on a supervised protocol, Gabriel's optimal 25-hydroxy vitamin D range is 50 to 75 ng/mL.
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Gabriel can find and book a practitioner who works with this approach.
Book with GabrielAbout Evidence Score
The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.
For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.