LDN (Low-Dose Naltrexone)
Off-label use of naltrexone, a prescription drug, at a low dose.
50/100
Bernard Bihari
Often ongoing; benefits usually judged over 2 to 3 months
7 phases
4 conditions
Protocol Overview
Off-label use of naltrexone, a prescription drug, at a low dose. At standard doses naltrexone blocks opioids; at low doses it is thought to modulate the immune system and raise endorphins. A licensed clinician decides whether it fits and the dose.
Used For
Key Resources
Safety Profile
Small randomized trials in fibromyalgia and Crohn's disease suggest benefit, but results are mixed and larger trials are needed. Studies in MS mostly looked at quality of life. Side effects are usually mild (vivid dreams, sleep changes, headache). Off-label and increasingly prescribed.
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The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.
For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.