Rapamycin (mTOR Modulation).

What it is

Rapamycin (sirolimus) is a prescription medicine first used at high doses to prevent organ transplant rejection. It dampens mTOR, a nutrient-sensing pathway that drives cell growth, which turns up autophagy, the cell's cleanup process.

In aging research it stands out: it has extended lifespan in yeast, worms and mice, including repeated mouse studies in the NIH-funded Interventions Testing Program. Physicians who prescribe it for longevity use a low dose once a week, off-label. Human studies are still early, and the Dog Aging Project is now testing it in pet dogs.

What happens at a visit

1. Baseline labs: blood count, metabolic panel, lipids, fasting insulin and inflammation markers.
2. A low dose taken once a week, often called pulsed dosing.
3. Monitoring labs every 3 to 6 months, including lipids, glucose and blood counts.
4. Possible mild side effects such as mouth sores or small lipid changes.
5. Your physician may pair it with other parts of a longevity plan.

Who it is for

• Adults over 40 who want a physician-guided longevity plan
• People interested in the research on mTOR and aging
• People working with a physician who will monitor labs regularly
• People already on a longevity plan who want to discuss adding it
• People tracking biological age and lab markers over time

Evidence and safety

The animal evidence for rapamycin is among the strongest of any longevity compound, but human data in healthy aging comes from small, short studies, and it isn't known whether it extends human life. Most safety data comes from transplant patients on much higher doses. Low weekly doses are usually well tolerated but need a prescription and regular labs. It can lower immune defenses and interacts with some medicines, and it isn't for pregnancy or people with weakened immunity.

How Gabriel helps