Senolytic Therapy.

What it is

As we age, some cells stop dividing but don't die off. These senescent cells build up and release inflammatory signals that can affect healthy tissue nearby. Senolytics are compounds that aim to clear them. The best-studied pairing is dasatinib, a prescription cancer medicine, with quercetin, a plant flavonoid; fisetin is another plant compound under study.

They are taken in short bursts, usually 2 to 3 days a month, rather than daily. Strong mouse research led to small human trials, including pilot studies at Mayo Clinic, with encouraging early signs. Physicians who prescribe them do so off-label.

What happens at a visit

1. Baseline labs such as CRP, IL-6, a metabolic panel and sometimes p16.
2. A short course, often dasatinib with quercetin for 2 to 3 days in a row.
3. Fisetin, if used, is also taken for a couple of days at a time.
4. Courses repeated monthly or every few months, as your physician advises.
5. Some people feel tired for a day or two after a course.
6. Follow-up labs at 3 to 6 months to track inflammation markers.

Who it is for

• Adults over 40 interested in proactive longevity care
• People with raised inflammation markers or a fast biological age
• People with idiopathic pulmonary fibrosis, through a clinical trial
• People with age-related chronic conditions, alongside their usual care
• People already on a longevity plan who want to add senolytics
• People with a family history of age-related disease

Evidence and safety

The evidence is strongest in animals. Human data comes from small early trials that are promising but not conclusive, and no senolytic is approved for aging. Dasatinib is a prescription cancer medicine with real side effects and drug interactions, so it needs a physician's oversight and lab monitoring, and it is not for pregnancy. Quercetin and fisetin are generally well tolerated. This is not a do-it-yourself protocol.

How Gabriel helps