Senolytic Therapy
Pharmaceutical clearing of senescent 'zombie' cells that drive aging and chronic disease
Availability varies by city. Gabriel can help find a practitioner or adjacent option.
During the visit
Baseline testing: p16INK4a levels, inflammatory markers (IL-6, TNF-alpha, CRP), metabolic panel
Protocol typically involves dasatinib + quercetin taken for 2-3 consecutive days
Repeated monthly or quarterly depending on senescence burden
Fisetin protocols: higher doses (1-2g) taken for 2 consecutive days monthly
Duration
2-3 days/month
Starting at
$200
Practitioner access
Ask Gabriel
Category
Longevity
About this treatment
What this treatment is designed to do
Senolytic therapy uses targeted pharmaceutical compounds to selectively destroy senescent cells — damaged cells that refuse to die and instead accumulate with age, secreting inflammatory signals (the SASP — senescence-associated secretory phenotype) that accelerate aging in surrounding healthy tissue. These 'zombie cells' are now recognized as a primary driver of aging and age-related diseases.
The most studied senolytic protocols combine dasatinib (a cancer drug that targets senescent cell survival pathways) with quercetin (a plant flavonoid that enhances the effect). Other emerging senolytics include fisetin (a strawberry-derived flavonoid showing remarkable results in animal studies) and navitoclax (BCL-2 inhibitor). These compounds are taken in periodic 'hit and run' doses — typically 2-3 days per month — rather than continuously.
Mayo Clinic research has demonstrated that clearing just 30% of senescent cells in mice extends healthspan by 36% and reverses multiple age-related conditions. Human trials at Mayo and other institutions are showing promising early results in idiopathic pulmonary fibrosis, diabetic kidney disease, and frailty. Longevity physicians are now prescribing senolytic protocols off-label for patients with elevated markers of cellular senescence.
Visit flow
What happens during the session
Baseline testing: p16INK4a levels, inflammatory markers (IL-6, TNF-alpha, CRP), metabolic panel
Protocol typically involves dasatinib + quercetin taken for 2-3 consecutive days
Repeated monthly or quarterly depending on senescence burden
Fisetin protocols: higher doses (1-2g) taken for 2 consecutive days monthly
Some patients report a 'clearing reaction' with mild fatigue for 24-48 hours post-dose
Follow-up labs at 3-6 months to measure reduction in inflammatory and senescence markers
Best for
Why people usually choose this
Adults 40+ interested in proactive longevity medicine
Anyone with elevated inflammatory markers and accelerated biological age
Patients with idiopathic pulmonary fibrosis (clinical trial indication)
Chronic disease patients with high senescent cell burden
Key outcomes
What people hope to improve
Targets a root cause of aging — senescent cell accumulation
Mayo Clinic research: 36% healthspan extension in animal models
Reduces chronic inflammation driven by SASP
Improves physical function and reduces frailty markers
Gabriel intelligence
How Gabriel makes this treatment more actionable
Treatment fit
Root-cause context before you book
Gabriel can help decide whether senolytic therapy fits your symptoms, labs, and recovery goals before you spend money on a session.
Protocol pairing
Connect sessions to a real plan
Gabriel can pair this with diagnostics, supplements, peptides, and follow-up cadence so it fits into a real protocol instead of sitting in isolation.
Practitioner match
Find the right clinic, not just the nearest one
Gabriel uses trust, treatment fit, and modality overlap to surface practitioners who are more likely to be a strong match for this exact treatment path.
Evidence & safety
What to know before committing
Strong preclinical evidence. Human clinical trials ongoing at Mayo Clinic and other institutions. Dasatinib has known side effects (it's a cancer drug) — requires physician oversight. Quercetin and fisetin have excellent safety profiles. This is NOT a DIY protocol — medical supervision essential for dasatinib-containing regimens.
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Use these when you want adjacent options in the same category before deciding what to book.
Not sure if this treatment is the right next move?
Tell Gabriel what you are dealing with and what you have already tried. You will get a more useful answer than a generic treatment directory can give.