Insulin Resistance Protocol

Most US adults have at least one marker of poor metabolic health, and insulin resistance sits behind type 2 diabetes, PCOS, fatty liver, metabolic syndrome and heart disease, and is linked to Alzheimer's disease. Frequent high insulin, from refined carbs and constant eating, makes cells less responsive to insulin over time. Fasting insulin is one of the earliest signs. HOMA-IR = (fasting insulin x fasting glucose) / 405. The approach has two sides: lower insulin exposure (fewer carbs, fewer eating windows) and improve insulin sensitivity (exercise, weight loss, sleep, supplements). Lifestyle change has strong evidence: in the Diabetes Prevention Program, about 7% weight loss with exercise cut progression to diabetes by 58%. Berberine has several trials with glucose effects similar to metformin. Inositol helps PCOS-related insulin resistance. Resistance training builds the muscle that clears glucose. For type 2 diabetes, remission is possible for some people: in the DiRECT trial (Lancet, 2018), 46% of people on a low-calorie diet program were in remission at 12 months, and in Virta's non-randomized ketogenic study (Hallberg, Diabetes Therapy, 2018), 60% of people who completed one year had an A1C under 6.5% on metformin alone or no diabetes medication. Remission is most likely earlier in the disease and with larger weight loss, and any medication change is made by your prescriber.