Protocolsmental health
mental healthLow

Pfeiffer Protocol (Biotype Testing)

Biochemical testing (blood histamine, copper, zinc, methylation) used to sort people into biotypes and recommend targeted nutrients.

Evidence Score

35/100

Developer

Carl Pfeiffer

Duration

3 to 6 months to judge benefit, then ongoing with retesting

Steps

15 phases

Used for

5 conditions

Protocol Overview

Biochemical testing (blood histamine, copper, zinc, methylation) used to sort people into biotypes and recommend targeted nutrients. Five main biotypes: undermethylation, overmethylation, copper overload, pyrrole disorder and normal. Used alongside psychiatric care.

Used For

DepressionAnxietyADHDSchizophrenia (alongside psychiatric care)Bipolar disorder (alongside psychiatric care)

Key Resources

"Nutrient Power" by William Walsh (student of Pfeiffer)
Walsh Research Institute

Supplements & Herbs

Safety Profile

Contraindications & Risks
Needs specialized testing and a trained practitioner. Bipolar disorder (SAMe can trigger mania). Treating the wrong biotype can worsen symptoms (for example copper-lowering in undermethylation). Pregnancy (high-dose nutrients only with a clinician)
Important Notes

Pfeiffer founded the Princeton Bio Center and reported treating more than 20,000 patients. The biotype percentages come from clinic records, not controlled trials, and tests such as urine kryptopyrrole are not validated. Testing can reveal nutrient imbalances worth correcting. If you are thinking about suicide or in crisis, call or text 988 (Suicide and Crisis Lifeline) or call 911.

Find a Practitioner

Gabriel can find and book a practitioner who works with this approach.

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EvidenceLow
Evidence Score35/100
Categorymental health
Duration3 to 6 months to judge benefit, then ongoing with retesting

About Evidence Score

The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.

For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.