Protocolsautoimmune
autoimmuneLow

Long COVID Recovery Protocol

Supportive protocol for persistent symptoms after COVID-19, aimed at inflammation, mast cell activation, energy and autonomic symptoms.

Evidence Score

40/100

Developer

Various long COVID clinics, integrative medicine

Duration

Highly variable: many improve over 3 to 18 months, some longer

Steps

26 phases

Used for

3 conditions

Protocol Overview

Supportive protocol for persistent symptoms after COVID-19, aimed at inflammation, mast cell activation, energy and autonomic symptoms. Evidence is early and mostly from small studies and clinical experience.

Used For

Long COVIDpost-acute sequelae of COVID-19PASC

Key Resources

Long COVID clinic protocols, COVID-OUT trial (Lancet Infectious Diseases, 2023), patient-led long COVID research groups

Supplements & Herbs

Safety Profile

Contraindications & Risks
All prescription options need a licensed clinician. Extra salt is not for people with high blood pressure, heart failure or kidney disease. Quercetin, NAC and other supplements can interact with medications: check with your prescriber or pharmacist. Exercising too early can trigger crashes. Work with a clinician experienced in long COVID
Important Notes

Long COVID affects a meaningful share of people after COVID-19. Common symptoms include fatigue with post-exertional malaise, brain fog, dysautonomia, breathing problems, mast cell symptoms and exercise intolerance. Proposed causes include ongoing inflammation, autoimmunity, viral persistence, mast cell activation, mitochondrial problems and autonomic dysfunction, and the picture often resembles ME/CFS. Pacing is central: activity can worsen PEM, so rest is part of the treatment, and heart rate or HRV tracking helps. Low-histamine eating and H1 plus H2 antihistamines help many people with mast cell symptoms. Low-dose naltrexone, CoQ10, D-ribose and B vitamins are used for energy, with small studies. Metformin during acute infection lowered long COVID risk in one trial; ivermectin did not. Hyperbaric oxygen has one small positive randomized trial. Recovery varies widely, from months to years. Your symptoms are real, and a clinician experienced in long COVID can help sort out what is driving them.

Find a Practitioner

Gabriel can find and book a practitioner who works with this approach.

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EvidenceLow
Evidence Score40/100
Categoryautoimmune
DurationHighly variable: many improve over 3 to 18 months, some longer

About Evidence Score

The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.

For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.