Protocolsnutrition
nutritionLow

Alzheimer's Risk Reduction Protocol (Bredesen ReCODE)

A multi-part protocol developed by Dr.

Evidence Score

40/100

Developer

Dale Bredesen

Duration

Risk reduction is lifelong; people with early symptoms often reassess after 6 to 12 months

Steps

24 phases

Used for

3 conditions

Protocol Overview

A multi-part protocol developed by Dr. Dale Bredesen that looks for many possible contributors to cognitive decline (insulin resistance, inflammation, hormones, toxins, sleep) and addresses each one. Used alongside care from a neurologist.

Used For

Mild cognitive impairmentearly Alzheimer's diseaseAlzheimer's risk reduction

Key Resources

The End of Alzheimer's by Dale Bredesen, "The End of Alzheimer's Program" by Dale Bredesen, research on multidomain lifestyle trials for dementia risk

Safety Profile

Contraindications & Risks
A complex protocol best done with a trained practitioner. Testing and supplements can be costly. Hormone therapy needs monitoring. Fasting and low-carb diets need a prescriber to adjust diabetes or blood pressure medicines first. Ginkgo, vitamin E and omega-3 can add to blood thinners. Sudden confusion or rapid decline needs prompt medical care
Important Notes

Bredesen's view is that Alzheimer's is the end result of many contributors (infections, inflammation, toxins, vascular and metabolic factors, loss of nutrient and hormone support), and his approach targets each one a person has. His published case series and a small 2022 proof-of-concept trial report improvement in some people with early decline, but there is no large controlled trial yet, so evidence is early. Many individual parts are well supported for brain health: exercise, blood sugar control, treating sleep apnea and hearing, and the multidomain FINGER trial showed better cognitive scores with diet, exercise, brain training and vascular care. ApoE4 carriers have higher risk and may benefit most from early action. The approach is used alongside care from a neurologist, including any standard treatments.

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EvidenceLow
Evidence Score40/100
Categorynutrition
DurationRisk reduction is lifelong; people with early symptoms often reassess after 6 to 12 months

About Evidence Score

The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.

For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.