Protocolsnutrition
nutritionLow-Moderate

Psoriasis Healing Protocol

A root-cause protocol for psoriasis that looks at the gut-skin connection, inflammation and immune balance, with diet, gut support and skin care alongside the care your dermatologist recommends.

Evidence Score

50/100

Developer

John Pagano, functional dermatology

Duration

3 to 6 months to judge change, then ongoing

Steps

24 phases

Used for

3 conditions

Protocol Overview

A root-cause protocol for psoriasis that looks at the gut-skin connection, inflammation and immune balance, with diet, gut support and skin care alongside the care your dermatologist recommends.

Used For

Psoriasisplaque psoriasispsoriatic arthritis

Key Resources

Healing Psoriasis by John Pagano
National Psoriasis Foundation dietary recommendations (Ford et al., JAMA Dermatology 2018)
Gut-skin axis research

Safety Profile

Contraindications & Risks
High-dose vitamin A is toxic over time and causes birth defects; keep supplements at or below 10,000 IU and avoid in pregnancy
Colonics and frequent enemas can cause dehydration, electrolyte imbalance and bowel injury; only under a clinician
Phototherapy and sun exposure raise skin cancer risk; never burn
Biologics and other systemic medicines raise infection risk and need monitoring by your dermatologist
Omega-3 and curcumin can add to blood thinner effects
Pregnancy or breastfeeding: ask your clinician before using these supplements
Important Notes

Psoriasis affects about 8 million Americans. It causes red, scaly plaques, often on the elbows, knees and scalp. It is not contagious and not caused by poor hygiene. It is linked to psoriatic arthritis (in about 1 in 3 people with psoriasis), heart and metabolic disease, and depression, so whole-body health matters. The Pagano protocol centers on diet and gut healing. It rests on the idea that a leaky gut lets substances into the bloodstream that the skin then reacts to. Research does show gut microbiome differences and increased gut permeability in psoriasis, but the protocol itself has not been tested in trials, and the evidence here is mostly for individual pieces. Celiac disease is about twice as common in psoriasis, and a gluten-free diet helps those with celiac disease or celiac antibodies. Weight loss improves psoriasis in trials. Omega-3 and vitamin D have some supporting studies. Strep throat can trigger guttate psoriasis, and strep needs prompt antibiotics from a clinician. Alcohol and stress clearly worsen psoriasis, so cutting alcohol and managing stress help. Narrowband UVB clears or nearly clears psoriasis in many people with moderate to severe disease. Biologics clear most or all plaques in many people with severe disease, with infection risk and monitoring. Diet and lifestyle steps help many people with mild to moderate psoriasis and work alongside the medicines that people with severe disease may need. Lowering whole-body inflammation also helps heart and joint health.

Find a Practitioner

Gabriel can find and book a practitioner who works with this approach.

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EvidenceLow-Moderate
Evidence Score50/100
Categorynutrition
Duration3 to 6 months to judge change, then ongoing

About Evidence Score

The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.

For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.