Protocolsautoimmune
autoimmuneLow

Lyme Disease Comprehensive Protocol

Integrative protocol for Lyme disease: prompt antibiotics from a clinician, plus herbal, immune and recovery support alongside them.

Evidence Score

40/100

Developer

ILADS, Richard Horowitz, integrative Lyme specialists

Duration

Weeks for early Lyme; months for persistent symptoms, guided by your clinician

Steps

17 phases

Used for

3 conditions

Protocol Overview

Integrative protocol for Lyme disease: prompt antibiotics from a clinician, plus herbal, immune and recovery support alongside them. Covers coinfections and persistent symptoms.

Used For

Lyme diseaseBorrelia burgdorferitick-borne infections

Key Resources

IDSA/AAN/ACR 2020 Lyme guideline, ILADS guidelines, "Why Can't I Get Better?" by Richard Horowitz, Buhner herbal protocols, ILADS clinician directory

Safety Profile

Contraindications & Risks
Long-term antibiotics are debated (IDSA advises against them for persistent nonspecific symptoms; ILADS supports them in some cases) and carry side effects. Doxycycline causes sun sensitivity and is generally avoided in pregnancy. Disulfiram has serious side effects and reacts dangerously with alcohol. Enzymes such as lumbrokinase and serrapeptase thin the blood. Chelation only under a clinician. Herxheimer reactions can be severe: tell your clinician
Important Notes

CDC estimates about 476,000 people are diagnosed and treated for Lyme disease in the US each year. It is caused by the bacterium Borrelia burgdorferi, spread by ticks. About 70 to 80% of infected people get an expanding rash, and many rashes are not the classic bull's-eye. Early Lyme responds well to prompt antibiotics, and that evidence is strong. Later Lyme can affect joints, nerves and the heart. Some people have lasting fatigue, pain or brain fog after treatment. IDSA calls this post-treatment Lyme disease syndrome; ILADS considers persistent infection possible. Randomized trials (including Berende, NEJM 2016) found that longer antibiotic courses did not improve quality of life for persistent symptoms, so the long-term approaches in this protocol rest on weaker evidence. Borrelia can form biofilms and persister forms in lab studies, which is why some clinicians use combinations and biofilm agents. Herbal protocols have lab evidence and many patient reports. Coinfections such as Babesia and Anaplasma need their own treatment. Low-dose naltrexone helps some people with pain. A clinician experienced in Lyme can help weigh these choices with you.

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EvidenceLow
Evidence Score40/100
Categoryautoimmune
DurationWeeks for early Lyme; months for persistent symptoms, guided by your clinician

About Evidence Score

The Evidence Score (0 to 100) rates the strength of evidence from studies in people for the uses listed: higher means stronger, more consistent research. It does not measure safety. It is not medical advice.

For education, not medical advice. Talk with a licensed clinician before you start, and never stop or change a prescribed medication without your prescriber.